Makowka L, Falk R E, Rotstein L E, Falk J A, Nossal N, Langer B, Blendis L M, Phillips M J
Science. 1980 Nov 21;210(4472):901-3. doi: 10.1126/science.7001630.
The survival of Lewis rats with D-galactosamine-induced fulminant hepatic failure was prolonged if they were given intraperitoneal injections of single-cell suspensions of liver or bone marrow cells from normal rats. Suspensions of liver cells were also effective in prolonging the survival of rats with ischemia-induced hepatic necrosis. The liver cells did not act by repopulating the recipient liver.
如果给D-半乳糖胺诱导暴发性肝衰竭的Lewis大鼠腹腔注射来自正常大鼠的肝细胞或骨髓细胞单细胞悬液，其存活时间会延长。肝细胞悬液在延长缺血诱导肝坏死大鼠的存活时间方面也有效。肝细胞的作用并非通过使受体肝脏重新细胞化来实现。
