花生四烯酸代谢、疼痛与痛觉过敏：非甾体类轻度镇痛药的作用方式
Arachidonic acid metabolism, pain and hyperalgesia: the mode of action of non-steroid mild analgesics.
作者信息
Higgs G A
出版信息
Br J Clin Pharmacol. 1980 Oct;10 Suppl 2(Suppl 2):233S-235S. doi: 10.1111/j.1365-2125.1980.tb01805.x.
Abstract
1 Cyclo-oxygenase products such as prostaglandins of the E series and prostacyclin produce the hyperalgesia associated with inflammation. 2 These substances may cause pain and incapacity in some inflammatory conditions. 3 Prostaglandin E2 sensitizes the chemical receptors of afferent pain endings to other inflammatory mediators such as bradykinin and histamine. 4 Unstable intermediates formed in the generation of prostaglandins may also play a role in the production of pain. 5 Drugs such as indomethacin and aspirin which are potent inhibitors of prostaglandin biosynthesis may exert their analgesic effect through this mechanism.
摘要
- 环氧化酶产物，如E系列前列腺素和前列环素，会产生与炎症相关的痛觉过敏。2. 这些物质在某些炎症状态下可能导致疼痛和功能丧失。3. 前列腺素E2使传入性痛觉末梢的化学感受器对其他炎症介质，如缓激肽和组胺敏感。4. 前列腺素生成过程中形成的不稳定中间体也可能在疼痛产生中起作用。5. 吲哚美辛和阿司匹林等药物是前列腺素生物合成的强效抑制剂，它们可能通过这种机制发挥镇痛作用。
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本文引用的文献
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SITE OF ACTION OF NARCOTIC AND NON-NARCOTIC ANALGESICS DETERMINED BY BLOCKING BRADYKININ-EVOKED VISCERAL PAIN.通过阻断缓激肽诱发的内脏疼痛来确定麻醉性和非麻醉性镇痛药的作用部位。
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