脑啡肽酶抑制剂的合理设计：从各种二肽的抑制效力研究脑啡肽酶的底物特异性。 - Suppr

Suppr

超能文献

Rational design of enkephalinase inhibitors: substrate specificity of enkephalinase studied from inhibitory potency of various dipeptides.

作者信息

Llorens C, Gacel G, Swerts J P, Perdrisot R, Fournie-Zaluski M C, Schwartz J C, Roques B P

出版信息

Biochem Biophys Res Commun. 1980 Oct 31;96(4):1710-6. doi: 10.1016/0006-291x(80)91371-6.

DOI:10.1016/0006-291x(80)91371-6

PMID:7004444

Abstract

摘要

相似文献

Rational design of enkephalinase inhibitors: substrate specificity of enkephalinase studied from inhibitory potency of various dipeptides.脑啡肽酶抑制剂的合理设计：从各种二肽的抑制效力研究脑啡肽酶的底物特异性。

Biochem Biophys Res Commun. 1980 Oct 31;96(4):1710-6. doi: 10.1016/0006-291x(80)91371-6.

Inhibitory potency of various peptides on enkephalinase activity from mouse striatum.各种肽对小鼠纹状体脑啡肽酶活性的抑制效力。

Biochem Biophys Res Commun. 1979 Nov 14;91(1):130-5. doi: 10.1016/0006-291x(79)90593-x.

Effect of various enkephalin analogs and dipeptides on the enzymatic activity of enkephalinase B isolated from calf-brain striatum.各种脑啡肽类似物和二肽对从小牛脑纹状体分离出的脑啡肽酶B酶活性的影响。

Life Sci. 1986 Mar 24;38(12):1111-8. doi: 10.1016/0024-3205(86)90247-x.

Inhibitors of calf-brain enkephalinase A and B.

Life Sci. 1983;33 Suppl 1:109-12. doi: 10.1016/0024-3205(83)90456-3.

New carboxyalkyl inhibitors of brain enkephalinase: synthesis, biological activity, and analgesic properties.

J Med Chem. 1983 Jan;26(1):60-5. doi: 10.1021/jm00355a013.

Complete differentiation between enkephalinase and angiotensin-converting enzyme inhibition by retro-thiorphan.通过逆-硫喷妥因实现脑啡肽酶与血管紧张素转换酶抑制作用的完全区分。

Proc Natl Acad Sci U S A. 1983 Jun;80(11):3178-82. doi: 10.1073/pnas.80.11.3178.

Enkephalinase: selective inhibitors and partial characterization.脑啡肽酶：选择性抑制剂及部分特性研究

Peptides. 1980 Spring;1(1):31-5. doi: 10.1016/0196-9781(80)90032-7.

Synthesis of enkephalinase B inhibitors, and their activity on isolated enkephalin-degrading enzymes.

Eur J Pharmacol. 1987 Mar 31;135(3):411-8. doi: 10.1016/0014-2999(87)90692-3.

Inhibition of porcine kidney "enkephalinase" by substituted-N-carboxymethyl dipeptides.取代的N-羧甲基二肽对猪肾“脑啡肽酶”的抑制作用。

Biochem Biophys Res Commun. 1982 Dec 31;109(4):1303-9. doi: 10.1016/0006-291x(82)91919-2.

Phosphoryl-Leu-Phe: a potent inhibitor of the degradation of enkephalin by enkephalinase.磷酰 - 亮氨酰 - 苯丙氨酸：一种强效的脑啡肽酶降解脑啡肽的抑制剂。

Eur J Pharmacol. 1981 Dec 3;76(2-3):299-300. doi: 10.1016/0014-2999(81)90520-3.

引用本文的文献

Dual Enkephalinase Inhibitors and Their Role in Chronic Pain Management.双重脑啡肽酶抑制剂及其在慢性疼痛管理中的作用。

Curr Pain Headache Rep. 2021 Mar 24;25(5):29. doi: 10.1007/s11916-021-00949-0.

Solid-Phase Insertion of -mercaptoalkylglycine Residues into Peptides.-巯基烷基甘氨酸残基的固相插入肽中。

Molecules. 2019 Nov 22;24(23):4261. doi: 10.3390/molecules24234261.

Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure.新型抗高血压和心力衰竭的肾素-血管紧张素系统及相关肽治疗方法。

Pharmacol Rev. 2019 Oct;71(4):539-570. doi: 10.1124/pr.118.017129.

Salovum egg yolk containing antisecretory factor as an adjunct therapy in severe cholera in adult males: a pilot study.含抗分泌因子的萨洛姆蛋黄作为成年男性重症霍乱辅助治疗的初步研究。

J Health Popul Nutr. 2011 Aug;29(4):297-302. doi: 10.3329/jhpn.v29i4.8443.

Brain-specific aminopeptidase: from enkephalinase to protector against neurodegeneration.脑特异性氨肽酶：从脑啡肽酶到神经退行性变的保护因子

Neurochem Res. 2007 Dec;32(12):2062-71. doi: 10.1007/s11064-007-9356-3. Epub 2007 May 3.

Efficacy and tolerability of racecadotril in the treatment of cholera in adults: a double blind, randomised, controlled clinical trial.消旋卡多曲治疗成人霍乱的疗效和耐受性：一项双盲、随机、对照临床试验。

Gut. 2003 Oct;52(10):1419-23. doi: 10.1136/gut.52.10.1419.

Evidence that Asn542 of neprilysin (EC 3.4.24.11) is involved in binding of the P2' residue of substrates and inhibitors.有证据表明，中性内肽酶（EC 3.4.24.11）的天冬酰胺542参与底物和抑制剂P2'残基的结合。

Biochem J. 1995 Oct 15;311 ( Pt 2)(Pt 2):623-7. doi: 10.1042/bj3110623.

Degradation of enkephalins: the search for an enkephalinase.脑啡肽的降解：寻找脑啡肽酶。

Mol Cell Biochem. 1982 Aug 20;47(1):35-43. doi: 10.1007/BF00241564.

Proc Natl Acad Sci U S A. 1983 Jun;80(11):3178-82. doi: 10.1073/pnas.80.11.3178.

Reduction of food intake by central administration of cholecystokinin octapeptide in the rat is dependent upon inhibition of brain peptidases.通过向大鼠中枢注射八肽胆囊收缩素减少食物摄入量取决于对脑肽酶的抑制作用。

Br J Pharmacol. 1989 Jan;96(1):236-42. doi: 10.1111/j.1476-5381.1989.tb11805.x.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验