卡托普利、沙拉新和溴隐亭对自发性高血压大鼠的降压作用。

Hypotensive effects of captopril, saralasin and bromocriptine in spontaneously hypertensive rats.

Hutchinson J S, Doyle A E

Clin Sci (Lond). 1980 Dec;59 Suppl 6:79s-82s. doi: 10.1042/cs059079s.

Abstract

Neurosecretion of peptides from superfused neurohypophyses in vitro was inhibited by dopamine. 2. This inhibition was dose-dependent. 3. Intravenous injection of the dopamine agonist, bromocriptine, lowered blood pressure in spontaneously hypertensive rats within 15 min. 4. Saralasin or captopril also lowered blood pressure of spontaneously hypertensive rats, but progressively over a period of 3 h. 5. The results suggest that dopamine and angiotensin have opposite effects on the neurosecretion of vasopressin. 6. Vasopressin appears to be involved in maintenance of blood pressure in the spontaneously hypertensive rat but is apparently not the only factor.

摘要

体外超灌流神经垂体中肽的神经分泌受到多巴胺的抑制。2. 这种抑制呈剂量依赖性。3. 静脉注射多巴胺激动剂溴隐亭可在15分钟内降低自发性高血压大鼠的血压。4. 沙拉新或卡托普利也可降低自发性高血压大鼠的血压，但在3小时内是逐渐降低的。5. 结果表明多巴胺和血管紧张素对加压素的神经分泌有相反的作用。6. 加压素似乎参与自发性高血压大鼠血压的维持，但显然不是唯一因素。