变应性支气管肺曲霉病患者中针对烟曲霉抗原的IgA抗体
IgA antibody against Aspergillus fumigatus antigen in patients with allergic bronchopulmonary aspergillosis.
作者信息
Patterson R, Roberts M, Ghory A C, Greenberger P A
出版信息
Clin Exp Immunol. 1980 Nov;42(2):395-8.
IgA antibodies against Aspergillus fumigatus (Af) antigen were measured by a radioimmunoassay in sera from patients with allergic bronchopulmonary aspergillosis (ABPA) and compared with IgA antibody levels in asthmatics who had positive prick tests to Af and normal controls. The assay for IgA antibody discriminated between both control groups and the ABPA group at two serum dilutions (10(-2) and 10(-3)) but did not discriminate all individual ABPA sera from the peak levels of antibody in the control groups. IgA antibody against Af may participate in the immunopathogenetics of pulmonary inflammation in some cases of ABPA and may be of some diagnostic value in some, but not all, cases.
采用放射免疫分析法检测了变应性支气管肺曲霉病（ABPA）患者血清中针对烟曲霉（Af）抗原的IgA抗体，并将其与对Af点刺试验呈阳性的哮喘患者及正常对照者的IgA抗体水平进行了比较。IgA抗体检测在两种血清稀释度（10⁻²和10⁻³）下能够区分两个对照组和ABPA组，但无法将所有ABPA患者血清与对照组抗体峰值水平区分开来。针对Af的IgA抗体在某些ABPA病例中可能参与肺部炎症的免疫发病机制，并且在部分（而非全部）病例中可能具有一定诊断价值。
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