Lichey J, Havestatt C, Weinmann J, Hasford J, Rietbrock N
Int J Clin Pharmacol Biopharm. 1978 Oct;16(10):460-2.
Digoxin concentration of 14 left ventricular papillary muscles and 36 right atrial appendages of 45 patients undergoing cardiac surgery were determined by the NEN 125J-radioimmunoassay. Blood specimens for digoxin assay were withdrawn immediately before operation, 12 to 16 hr after the last digitalis dose. Mean papillary muscle digoxin concentration was 76.1 ng/g +/- 25.5; mean ratio to plasma digoxin level, 36.8:1. The mean concentration of right atrial appendages was 41.8 ng/g; mean ratio, 29.9:1. Most of the tissue specimens were examined histologically using Hematoxylin-Eosin and van Gieson stains. No clear relation between tissue digoxin concentration and hisological alteration, i.e., the degree of fibrosis or lipomatosis, could be found, although most severe alterations were found in right atrial appendages corresponding to a higher variation in tissue concentrations and a poorer correlation to plasma digoxin (r = 0.47, respectively for papillary muscle r = 0.73).
采用NEN 125J放射免疫分析法测定了45例心脏手术患者的14块左心室乳头肌和36个右心耳的地高辛浓度。术前、最后一剂洋地黄用药后12至16小时立即采集用于地高辛测定的血样。乳头肌地高辛平均浓度为76.1 ng/g±25.5；与血浆地高辛水平的平均比值为36.8:1。右心耳的平均浓度为41.8 ng/g；平均比值为29.9:1。大多数组织标本采用苏木精-伊红染色和范吉森染色进行组织学检查。尽管在右心耳中发现了最严重的改变，对应于组织浓度的较高变化以及与血浆地高辛的较差相关性（乳头肌r = 0.73，右心耳r = 0.47），但未发现组织地高辛浓度与组织学改变（即纤维化或脂肪变性程度）之间存在明确关系。
