人体和兔子体内的前列环素与血糖水平
Prostacyclin and blood glucose levels in humans and rabbits.
作者信息
Dembińska-Kieć A, Kostka-Trabka E, Grodzińska L, Zmuda A, Bieroń K, Kedzior A, Ochmański W, Zelazny T
出版信息
Prostaglandins. 1981 Jan;21(1):113-21. doi: 10.1016/0090-6980(81)90201-x.
PMID:7010454
Abstract
In patients with peripheral vascular disease and in healthy rabbits, infusion of PGI2 but not of 6-keto PGF1 alpha induced a rise in blood glucose level and a pathological deviation in glucose tolerance test. In experiments in vitro, the increased concentrations of glucose produced dose-dependent inhibition of PGI2 release from isolated rat aortic rings. The link between PGI2 and carbohydrate metabolism is discussed.
摘要
在患有外周血管疾病的患者以及健康兔子中，输注前列环素（PGI2）而非6-酮-前列腺素F1α（6-keto PGF1α）会导致血糖水平升高以及葡萄糖耐量试验出现病理偏差。在体外实验中，葡萄糖浓度的升高对分离出的大鼠主动脉环释放前列环素产生了剂量依赖性抑制。文中讨论了前列环素与碳水化合物代谢之间的联系。
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