Bardin C W, Catterall J F
Science. 1981 Mar 20;211(4488):1285-94. doi: 10.1126/science.7010603.
Sexual dimorphism in selected extragenital tissues is described with emphasis on the molecular basis of the differences. Testosterone rather than 5 alpha-dihydrotestosterone appears to be the major intracellular androgen in organs other than skin and reproductive tract, but other steroid metabolites and their receptors are required to produce the diverse tissue differences observed in males and females. There is also evidence that multiple hormones from several endocrine glands are required to act in concert with androgens to produce and maintain their effects. Although many of the consequences of sexual dimorphism, such as body size and strength, have been evident for centuries, other differences between males and females such as disease incidence, response to drugs and toxins, and the metabolism and assimilation of dietary constituents have only recently been discovered.
本文描述了特定生殖器外组织中的性别二态性，并着重阐述了这些差异的分子基础。除皮肤和生殖道外，睾酮而非5α-二氢睾酮似乎是其他器官中的主要细胞内雄激素，但其他类固醇代谢产物及其受体对于产生雄性和雌性中观察到的多种组织差异是必需的。也有证据表明，来自多个内分泌腺的多种激素需要与雄激素协同作用才能产生并维持其效应。尽管性别二态性的许多后果，如体型和力量，几个世纪以来一直很明显，但男性和女性之间的其他差异，如疾病发病率、对药物和毒素的反应以及膳食成分的代谢和同化，直到最近才被发现。
