新型β受体激动剂-黄嘌呤衍生物瑞普特罗对乙酰甲胆碱诱导的支气管收缩的抑制作用。

Inhibition of methacholine-induced bronchoconstriction with reproterol, a new beta agonist-xanthine derivative.

作者信息

Klaustermeyer W B, Kuhn G J, Santiago S M, Wehiky I, Hunt E J

出版信息

Ann Allergy. 1981 Apr;46(4):189-92.

Abstract

This study compared the efficacy of single oral doses of a new beta adrenergic agonist-xanthine derivative, reproterol, with placebo by measuring the degree of induced bronchodilation and inhibition of response to methacholine challenge in patients with bronchial asthma. In comparison with placebo, 30 mg reproterol was an effective bronchodilator. Attenuation of the response, but not complete blockage of the methacholine-induced bronchoconstriction, was observed with 30 mg reproterol. Methacholine-induced bronchoconstriction is of use in assessing effect and mechanism of the action of new pharmacologic agents.

摘要

本研究通过测量支气管哮喘患者诱导的支气管扩张程度以及对乙酰甲胆碱激发反应的抑制情况，比较了新型β肾上腺素能激动剂-黄嘌呤衍生物瑞普特罗单次口服剂量与安慰剂的疗效。与安慰剂相比，30毫克瑞普特罗是一种有效的支气管扩张剂。使用30毫克瑞普特罗时，观察到乙酰甲胆碱诱导的支气管收缩反应减弱，但并非完全阻断。乙酰甲胆碱诱导的支气管收缩可用于评估新型药物的作用效果和作用机制。