Finiguerra M, De Martini S, Negri L, Simonelli A
Minerva Med. 1981 May 26;72(21):1353-60.
A double-blind study has been carried out in adult patients suffering from acute and chronic bronchitis, and acute exacerbation of chronic hypersecretory bronchitis, excluding the bronchorreic forms, in order to evaluate the mucolytic activity of orally given domiodol and sobrerol. Treatment with both drugs resulted in an improvement in the subjective measures of ease of expectoration, severity of coughing and sputum consistency; however, there was no improvement in respiratory functions. Moreover, domiodol resulted in a significant increase in sputum volumes, since the very first days of treatment.
为评估口服多尼溴铵和索布瑞醇的黏液溶解活性,对患有急慢性支气管炎以及慢性分泌过多性支气管炎急性加重(不包括支气管溢液型)的成年患者进行了一项双盲研究。两种药物治疗均使咳痰难易程度、咳嗽严重程度和痰液黏稠度等主观指标有所改善;然而,呼吸功能并无改善。此外,从治疗的第一天起,多尼溴铵就使痰量显著增加。