Ferrero E, Casale G, Ricci C, Ravecca D
Minerva Med. 1981 May 19;72(20):1289-94.
In a group of subjects with a known family history of diabetes (subjects with high risk of diabetes) and in two control groups, one of normal subjects and the other of poorly controlled insulin-dependent diabetic patients, all with normal blood levels of cholesterol and triglyceride, the fasting HbA1c concentration and the glycemic and insulin response to OGTT (1 g/kg of body weight) were studied. A prompt increase in serum insulin was observed both in normals and in subjects with a known family history of diabetes (poor in diabetics, of course), but insulin peak was significantly higher in the second ones. As in diabetes patients as in subjects with a known family history of diabetes, the HbA1c levels were significantly higher than in normal subjects, but significantly less high in subjects with a known family history of diabetes than in diabetics. These data might suggest that the prediabetic states generally joint with hyperinsulinemia and the HbA1c determination could contribute to the selection of those prediabetic states.
在一组有已知糖尿病家族史的受试者（糖尿病高危人群）以及两个对照组中，一个对照组为正常受试者，另一个对照组为胰岛素依赖型糖尿病控制不佳的患者，所有受试者的胆固醇和甘油三酯血液水平均正常，研究了空腹糖化血红蛋白（HbA1c）浓度以及对口服葡萄糖耐量试验（OGTT，1g/kg体重）的血糖和胰岛素反应。正常受试者以及有已知糖尿病家族史的受试者（当然，糖尿病患者中该反应较弱）均观察到血清胰岛素迅速升高，但后者的胰岛素峰值显著更高。与糖尿病患者一样，有已知糖尿病家族史的受试者的HbA1c水平显著高于正常受试者，但有已知糖尿病家族史的受试者的HbA1c水平显著低于糖尿病患者。这些数据可能表明，糖尿病前期状态通常与高胰岛素血症相关，并且HbA1c测定有助于筛选出那些糖尿病前期状态。
