Adamson U, Grill V, Efendić S
Acta Diabetol Lat. 1981 Apr-Jun;18(2):173-9. doi: 10.1007/BF02099003.
The effects of previous exposure to glucose on the insulin, glucagon, growth hormone and blood glucose responses to subsequent stimulation with L-arginine were investigated in normal man. During control conditions (i.e., after 120 min of saline infusion), the i.v. administration of arginine enhanced the release of all three hormones and caused a small and transient rise in blood glucose. When arginine was preceded by i.v. glucose during 0-60 min, followed by a 'rest period' of 60-120 min, the insulin release induced by the amino acid was further enhanced, glucagon and GH release were unaffected and blood glucose depressed below control levels. When arginine was preceded by a small oral glucose load (0.5 g/kg) the initial insulin response to arginine was augmented, the initial glucagon response was slightly but significantly depressed and blood glucose lowered while the growth hormone response was unaffected.
(1) a near-physiological intake of glucose increases insulin and depresses glucagon secretion evoked by amino acids resulting in increased glucose disposal; (2) the modifications of the insulin and glucagon responses constitute separate components in the feed-back regulation of glucose homeostasis.
在正常男性中研究了先前接触葡萄糖对随后用L-精氨酸刺激时胰岛素、胰高血糖素、生长激素和血糖反应的影响。在对照条件下（即输注生理盐水120分钟后），静脉注射精氨酸可增强所有三种激素的释放，并使血糖出现小幅短暂升高。当在0 - 60分钟内静脉注射葡萄糖后再注射精氨酸，随后有60 - 120分钟的“休息期”时，氨基酸诱导的胰岛素释放进一步增强，胰高血糖素和生长激素释放未受影响，血糖降至对照水平以下。当在口服少量葡萄糖负荷（0.5 g/kg）后再注射精氨酸时，对精氨酸的初始胰岛素反应增强，初始胰高血糖素反应略有但显著降低，血糖降低，而生长激素反应未受影响。
（1）接近生理摄入量的葡萄糖会增加胰岛素分泌并抑制氨基酸引起的胰高血糖素分泌，从而导致葡萄糖处置增加；（2）胰岛素和胰高血糖素反应的改变是葡萄糖稳态反馈调节中的独立组成部分。
