Nisbet N W, Menage J
Br J Exp Pathol. 1981 Jun;62(3):215-21.
In ossicles derived from grafts of compatible intact bone marrow in the subcapsular renal site the ectopic bone remains of donor provenance but the haemopoietic elements are partially replaced with tissue by host cells derived from stem cells migrating from the blood. Ossicles derived from incompatible intact bone marrow grafted in immunologically tolerant recipients are morphologically identical to those derived from compatible intact bone marrow. On abolition of the tolerance the allogeneic ectopic bone and donor microenvironment for haemopoiesis became manifest: haemopoietic marrow, even the host elements, was rapidly lost, bone disappearing rapidly if recently established, slowly if long established. Provided the state of immunological tolerance persists, the histoincompatible bone and microenvironment of the donor co-exist with marrow derived from the circulating haemopoietic stem cells of the tolerant recipient.
在肾被膜下部位植入相容的完整骨髓移植物所形成的小骨中，异位骨保留了供体来源，但造血成分部分被从血液迁移而来的干细胞所产生的宿主细胞组织所替代。植入免疫耐受受体体内的不相容完整骨髓所形成的小骨在形态上与植入相容完整骨髓所形成的小骨相同。一旦耐受性消除，异基因异位骨和供体造血微环境就会显现出来：造血骨髓，甚至宿主成分，会迅速丢失，新形成的骨会迅速消失，形成时间长的则消失缓慢。只要免疫耐受状态持续存在，供体的组织不相容骨和微环境就会与来自耐受受体循环造血干细胞的骨髓共存。
