Fujimura S, Sohara Y, Kondo T, Yamauchi A, Handa M, Okabe T, Nakada T
Tohoku J Exp Med. 1980 Dec;132(4):443-52. doi: 10.1620/tjem.132.443.
A technical modification in pulmonary venous anastomosis is presented for one-stage bilateral lung autotransplantation in dogs. This method nullified or minimized both narrowing and loss of vascular distensibility due to scar formation at anastomotic line which inevitably resulted in functional defects after the operation. In this new procedure, bilateral pulmonary arteries were anastomosed using angioplastic techniques and both right and left pulmonary veins were sutured orthotopically as a single atrial cuff. Of 11 dogs which underwent one-stage bilateral lung replantation, 6 survived after operation. Sites of vascular anastomoses in the long-term survivors showed no narrowing due to scar formation at autopsy after hemodynamic examination. In these animals rapid and continuing infusion of 2000 to 3000 ml of blood or plasma explander was performed within 15 min through an intraatrial catheter. Various hemodynamic values were measured simultaneously. In the dog with bilateral lung transplants pulmonary arterial pressure showed linear increase with an increase in cardiac output when compared with control animal studies. It could be interpreted from these results that some changes occurred in the mechanism of pulmonary circulation of the transplant.
本文介绍了一种用于犬双侧肺一期自体移植的肺静脉吻合技术改进方法。该方法消除或最小化了吻合口处因瘢痕形成导致的血管狭窄和扩张性丧失，而这不可避免地会导致术后功能缺陷。在这一新手术中，采用血管成形技术吻合双侧肺动脉，并将右肺静脉和左肺静脉作为一个单一的心房袖套进行原位缝合。在接受双侧肺一期再植的11只犬中，6只术后存活。长期存活犬的血管吻合部位在血流动力学检查后的尸检中未显示因瘢痕形成而导致的狭窄。在这些动物中，通过心房内导管在15分钟内快速持续输注2000至3000毫升血液或血浆扩容剂。同时测量各种血流动力学值。与对照动物研究相比，双侧肺移植犬的肺动脉压随心输出量增加呈线性升高。从这些结果可以推断，移植肺的肺循环机制发生了一些变化。
