葡萄糖依赖性促胰岛素多肽的作用。

Actions of GIP.

作者信息

Brown J C, Dahl M, Kwauk S, McIntosh C H, Otte S C, Pederson R A

出版信息

Peptides. 1981;2 Suppl 2:241-5. doi: 10.1016/0196-9781(81)90038-3.

Abstract

Two structurally similar peptides were isolated from a preparation of GIP using an HPLC system. The major peptide corresponds to GIP1-42 and the minor has the sequence GIP3-42. GIP1-42 has both insulinotropic and somatostatinotropic activities, whereas GIP3-42 has only insignificant activity. GIP was also shown to potentiate insulin release initiated by D-glyceraldehyde, L-leucine/L-glutamine and 2-keto-isocaproic acid. No potentiation was observed with 2-ketocaproate. The 4 substrates studied are all metabolized but via different mechanisms.

摘要

使用高效液相色谱系统从胃抑制多肽（GIP）制剂中分离出两种结构相似的肽。主要肽对应于GIP1 - 42，次要肽的序列为GIP3 - 42。GIP1 - 42具有促胰岛素分泌和促生长抑素分泌活性，而GIP3 - 42仅具有微不足道的活性。GIP还被证明可增强由D - 甘油醛、L - 亮氨酸/L - 谷氨酰胺和2 - 酮异己酸引发的胰岛素释放。2 - 酮己酸盐未观察到增强作用。所研究的4种底物均被代谢，但通过不同机制。