Davies A, Dixon M, Callanan D, Huszczuk A, Widdicombe J G, Wise J C
Respir Physiol. 1978 Jul;34(1):83-101. doi: 10.1016/0034-5687(78)90050-6.
Anaesthetized rabbits were given 200 ppm sulphur dioxide to breathe for 10 min. This abolished activity in 23 of 26 pulmonary stretch receptors, while leaving that of lung irritant receptors unimpaired. The Breuer-Hering reflex was abolished and breathing became deeper and slower. Inspiratory time (tI) was increased and expiratory time (tE) decreased. Subsequent vagotomy increased tidal volume (VT), tI and tE. In animals with stretch receptors blocked, injections of phenyl diguanide and histamine still increased breathing frequency and decreased VT, indicating that reflexes from lung irritant and J-receptors were intact. Inhalation of 8% CO2 caused a bigger increase in frequency and tidal volume in rabbits with stretch receptor block compared with controls or those after vagotomy. Induction of pneumothorax with stretch receptor block transiently prolonged tI and shortened tE; removal of the pneumothorax also transiently shortened tE and usually also decreased tI. The results suggest that lung irritant receptors reflexly shorten tE in all our experimental conditions, but have various effects on tI which may depend on the timing of the irritant receptor discharge and refractoriness of the inspiratory response.
给麻醉的兔子吸入200 ppm的二氧化硫，持续10分钟。这使26个肺牵张感受器中的23个的活动消失，而肺刺激感受器的活动未受影响。布雷尔 - 黑林反射消失，呼吸变得更深、更慢。吸气时间（tI）增加，呼气时间（tE）减少。随后切断迷走神经增加了潮气量（VT）、tI和tE。在牵张感受器被阻断的动物中，注射苯基双胍和组胺仍会增加呼吸频率并降低VT，这表明来自肺刺激感受器和J感受器的反射是完整的。与对照组或切断迷走神经后的动物相比，吸入8%的二氧化碳会使牵张感受器被阻断的兔子的频率和潮气量增加得更多。在牵张感受器被阻断的情况下诱发气胸会短暂延长tI并缩短tE；去除气胸也会短暂缩短tE，并且通常也会减少tI。结果表明，在我们所有的实验条件下，肺刺激感受器会反射性地缩短tE，但对tI有不同的影响，这可能取决于刺激感受器放电的时间和吸气反应的不应期。
