α-氨基己二酸的神经胶质毒性和抗神经毒性作用的立体特异性
Stereospecificity of the gliotoxic and anti-neurotoxic actions of alpha-aminoadipate.
作者信息
Olney J W, de Gubareff T, Collins J F
出版信息
Neurosci Lett. 1980 Oct 2;19(3):277-82. doi: 10.1016/0304-3940(80)90273-6.
The glutamate (Glu) analog, DL-alpha-aminoadipate (DL-alpha AA), and the separate D and L isomers of alpha AA, were administered subcutaneously to infant mice and histopathological effects on the arcuate hypothalamic (AH) nucleus were studied. L-alpha AA induced striking gliotoxic and neurotoxic changes; D-alpha AA and DL-alpha AA respectively induced mild and extreme gliotoxic but not neurotoxic changes. The neurotoxicity of L-alpha AA is of interest in view of its known neuroexcitatory potential. The non-neurotoxicity of DL-alpha AA implies effective antagonism by D-alpha AA of the neurotoxicity of L-alpha AA, which is of interest in that D-alpha AA is recognized as an effective antagonist of amino acid excitants and is thought to block specifically at the excitatory receptor.
将谷氨酸（Glu）类似物DL-α-氨基己二酸（DL-α-AA）以及α-AA的D型和L型异构体分别皮下注射给幼鼠，并研究其对弓状下丘脑（AH）核的组织病理学影响。L-α-AA引起显著的神经胶质毒性和神经毒性变化；D-α-AA和DL-α-AA分别引起轻度和极度神经胶质毒性变化，但无神经毒性变化。鉴于L-α-AA已知的神经兴奋潜能，其神经毒性值得关注。DL-α-AA的无神经毒性意味着D-α-AA对L-α-AA的神经毒性具有有效的拮抗作用，这一点很有趣，因为D-α-AA被认为是氨基酸兴奋性递质的有效拮抗剂，并且被认为特异性地阻断兴奋性受体。
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