Altland P D
Aviat Space Environ Med. 1982 Jan;53(1):44-8.
Young (age 2 months) and middle-aged (age 10 month) rats were injected once with a culture of Streptococcus sanguis and exposed for 24 h to 7620 m altitude. At 6 d 54% of the exposed and 30% of the unexposed middle-aged rats had bacterial endocarditis. Myocarditis developed in 63% of the injected exposed rats of both ages, in 11% of the injected unexposed middle-aged rats, and in none of the unexposed young adults. Interstitial nephritis was found in 46-66% of the injected, unexposed young and middle-aged rats and in 70-86% of the injected, exposed young and middle-aged rats, respectively. About 95% of all injected rats survived 6 d. No evidence of hemoconcentration was found. The increase in cardiac disease induced by altitude was probably due to deleterious effects of hypoxia on the myocardium, and cellular defenses, and to physiological and possible immunological changes associated with aging.
将2月龄幼鼠和10月龄中年大鼠一次性注射血链球菌培养物，并使其在海拔7620米的高度暴露24小时。6天时，暴露组中54%的中年大鼠和未暴露组中30%的中年大鼠患有细菌性心内膜炎。两个年龄段的注射暴露组大鼠中63%发生了心肌炎，注射未暴露组中年大鼠中有11%发生了心肌炎，未暴露的年轻成年大鼠中无一发生心肌炎。分别在46%-66%的注射未暴露的幼鼠和中年大鼠以及70%-86%的注射暴露的幼鼠和中年大鼠中发现间质性肾炎。所有注射大鼠中约95%存活了6天。未发现血液浓缩的迹象。海拔引起的心脏病增加可能是由于缺氧对心肌、细胞防御的有害影响，以及与衰老相关的生理和可能的免疫变化。
