甲氧苄啶/磺胺甲恶唑相关性假膜性结肠炎

Trimethoprim/sulfamethoxazole-associated pseudomembranous colitis.

作者信息

Scott S A

出版信息

Drug Intell Clin Pharm. 1982 Mar;16(3):244-6. doi: 10.1177/106002808201600308.

DOI:10.1177/106002808201600308

Abstract

A case of TMP/SMX-associated pseudomembranous colitis is described in a patient being treated for a urinary tract infection. Pseudomembranes are visualized on proctosigmoidoscopy, and stool cultures identified Clostridium difficile as the causative organism. The patient was treated successfully with oral vancomycin. A review of this infrequently reported adverse reaction to TMP/SMX is presented, emphasizing etiology and treatment.

摘要

本文描述了一例在接受尿路感染治疗的患者中发生的与复方磺胺甲恶唑相关的伪膜性结肠炎病例。在直肠乙状结肠镜检查中可见伪膜，粪便培养确定艰难梭菌为病原体。该患者口服万古霉素治疗成功。本文对这种复方磺胺甲恶唑罕见不良反应进行了综述，重点强调了病因和治疗方法。