Pedersen L, Gyldensted C
Acta Neurol Scand. 1978 Aug;58(2):81-8. doi: 10.1111/j.1600-0404.1978.tb02864.x.
Thirty-nine patients with hereditary ataxia (HA), hereditary spastic paraplegia or Charcot-Marie-Tooth disease were investigated with computerized cranial tomography (CT). Infratentorial as well as supratentorial atrophies were registrated and scored. These were compared with the patient's neurological symptoms, which were related to the lesion in the central nervous system, and scored. There was correlation between the distribution of brainstem/cerebellar symptoms and the distribution and degree of infratentorial atrophy. HA cases with cerebral cortical atrophy had significantly higher dementia scores than those without wide sulci. Intravenous injection with contrast medium was of no diagnostic aid, as no focal changes were found. It is concluded that CT is an aid in the diagnosis of hereditary ataxias and hereditary spastic paraplegia.
对39例患有遗传性共济失调（HA）、遗传性痉挛性截瘫或夏科-马里-图斯病的患者进行了计算机断层扫描（CT）检查。记录并评估幕下和幕上萎缩情况。将这些结果与患者与中枢神经系统病变相关的神经症状进行比较并评分。脑干/小脑症状的分布与幕下萎缩的分布和程度之间存在相关性。有大脑皮质萎缩的HA病例的痴呆评分显著高于无脑沟增宽的病例。静脉注射造影剂无助于诊断，因为未发现局灶性改变。结论是CT有助于遗传性共济失调和遗传性痉挛性截瘫的诊断。
