Aellig W H, Nüesch E, Pacha W
Eur J Clin Pharmacol. 1982;21(6):451-5. doi: 10.1007/BF00542037.
In a cross-over pharmacokinetic study in 8 healthy volunteers a retard formulation containing pindolol 30 mg was compared with the normal 15 mg. pindolol tablet. The pindolol 30 mg retard tablet led to the same maximum plasma level as a single dose of the normal pindolol tablet. A plasma concentration higher than half of the maximum was maintained twice as long after the retard than after the normal 15 mg pindolol tablet. The bioavailability of the two forms was practically identical.
在一项针对8名健康志愿者的交叉药代动力学研究中，将含30毫克吲哚洛尔的缓释制剂与普通的15毫克吲哚洛尔片剂进行了比较。30毫克吲哚洛尔缓释片产生的最大血浆水平与单剂量普通吲哚洛尔片剂相同。服用缓释片后，血浆浓度高于最大浓度一半的时间是服用15毫克普通吲哚洛尔片剂后的两倍。两种剂型的生物利用度实际上是相同的。
