二硫化碳对大鼠肝毒性作用的变异：多基因遗传的证据。
Variation in the hepatotoxic effects of carbon disulphide in the rat: evidence for polygenic inheritance.
作者信息
Lovell D P, Tucker S P, Cunningham V J
出版信息
Toxicol Lett. 1982 Jan;10(1):11-6. doi: 10.1016/0378-4274(82)90260-0.
PMID:7080064
Abstract
The hepatotoxic effects of carbon disulphide have been examined in rats obtained from a series of crosses between two inbred strains which differ widely in their susceptibility. The distribution of susceptibility in the F2 generation indicates that the variation cannot be explained by a simple genetic model. A polygenic model is a more likely explanation.
摘要
已经在来自两个近交系之间一系列杂交的大鼠中研究了二硫化碳的肝毒性作用，这两个近交系在易感性上差异很大。F2代中易感性的分布表明，这种变异不能用简单的遗传模型来解释。多基因模型是更有可能的解释。
Zotero 插件