Variation in the hepatotoxic effects of carbon disulphide in the rat: evidence for polygenic inheritance.
作者信息
Lovell D P, Tucker S P, Cunningham V J
出版信息
Toxicol Lett. 1982 Jan;10(1):11-6. doi: 10.1016/0378-4274(82)90260-0.
PMID:7080064
Abstract
The hepatotoxic effects of carbon disulphide have been examined in rats obtained from a series of crosses between two inbred strains which differ widely in their susceptibility. The distribution of susceptibility in the F2 generation indicates that the variation cannot be explained by a simple genetic model. A polygenic model is a more likely explanation.
摘要
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