苯并(a)芘酚衍生物与大鼠和小鼠肝脏微粒体的葡萄糖醛酸化动力学。
Kinetics of glucuronidation of phenol-derivatives of benzo(a)pyrene with rat and mouse liver microsomes.
作者信息
Nemoto N, Takayama S
出版信息
Toxicol Lett. 1982 Jan;10(1):75-9. doi: 10.1016/0378-4274(82)90270-3.
PMID:7080072
Abstract
The kinetics of glucuronidation with 3- and 9-hydroxybenzo(a)pyrene (3-OH BP and 9-OH BP) were studied using rat and mouse liver microsomes. The UDP-glucuronyl transferase had two apparent Km values for 3- and 9-OH BP in both species, suggesting that the hepatic enzyme is efficient in glucuronidation of first-phase metabolites, especially at low concentrations of the carcinogen.
摘要
利用大鼠和小鼠的肝脏微粒体研究了3-羟基苯并(a)芘和9-羟基苯并(a)芘（3-OH BP和9-OH BP）的葡萄糖醛酸化动力学。在这两个物种中，UDP-葡萄糖醛酸基转移酶对3-OH BP和9-OH BP均有两个表观Km值，这表明该肝脏酶在第一阶段代谢产物的葡萄糖醛酸化过程中效率较高，尤其是在致癌物浓度较低时。
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