Thomson I A, Hughes R L, Fitch W, Campbell D
Anaesthesia. 1982 May;37(5):548-53. doi: 10.1111/j.1365-2044.1982.tb01225.x.
The effects of increasing concentrations of nitrous oxide 30, 50 and 70% on the hepatic circulation and hepatic oxygen consumption were investigated in seven normocapnic greyhounds. Hepatic arterial and portal venous blood flows were measured continuously using electromagnetic flow probes, and mean arterial pressure and cardiac output monitored. The administration of nitrous oxide caused linear decreases in hepatic arterial, portal venous and total liver blood flows. Increases in mean arterial pressure, hepatic arterial resistance and mesenteric vascular resistance were noted. There were no significant changes in hepatic oxygen consumption. It is suggested that the decrease in liver blood flow may result from alpha-adrenoceptor stimulation.
在7只正常碳酸血症的灵缇犬中，研究了浓度分别为30%、50%和70%的一氧化二氮浓度增加对肝循环和肝脏氧消耗的影响。使用电磁流量探头连续测量肝动脉和门静脉血流量，并监测平均动脉压和心输出量。一氧化二氮的给药导致肝动脉、门静脉和肝脏总血流量呈线性下降。观察到平均动脉压、肝动脉阻力和肠系膜血管阻力增加。肝脏氧消耗没有显著变化。提示肝血流量的减少可能是由于α-肾上腺素能受体刺激所致。
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