Corash L, Shafer B
Blood. 1982 Jul;60(1):166-71.
An experimental model using asplenic rabbits injected with radioactive amino acids has been developed to examine the density distribution of newly released platelets. Platelets from asplenic rabbits had a larger mean volume and greater protein content than those from asplenic animals. Radiolabel, indicative of new platelets, is preferentially incorporated into the most dense platelets during the early postinjection period. Platelets of intermediate density also demonstrated augmented early label incorporation compared to the lightest cells, In contrast, during the late postinjection phase, there is preferential labeling of the least dense platelets. The specific radioactivity of heavy and light platelets rises to approximately equal levels, and falls abruptly, but the peak activities occur at distinctly separate times consistent with the concept of platelet density modification during platelet aging. Although platelet biologic properties are broadly distributed, these studies support the concept that on the average young platelets have an increased density and become less dense as they circulate.
已建立一种实验模型，即给无脾兔注射放射性氨基酸，以检查新释放血小板的密度分布。无脾兔的血小板比有脾动物的血小板平均体积更大，蛋白质含量更高。在注射后早期，指示新血小板的放射性标记优先掺入密度最高的血小板中。与最轻的细胞相比，中等密度的血小板在早期也显示出标记掺入增加。相反，在注射后晚期，密度最低的血小板有优先标记。重血小板和轻血小板的比放射性上升到大致相等的水平，然后突然下降，但峰值活性出现在明显不同的时间，这与血小板老化过程中血小板密度改变的概念一致。尽管血小板的生物学特性分布广泛，但这些研究支持这样的概念，即平均而言，年轻血小板密度增加，在循环过程中密度变小。
