吲哚拉明和普萘洛尔对高血压患者冷刺激心血管反应的影响。

Effect of indoramin and propranolol on cardiovascular response to cold in hypertensive patients.

作者信息

Velasco M, Urbina-Quintana A, Andrews-Figueroa P, Nieves D, Hernández E, Guevara-Casado J, Hernández-Pieretti O

出版信息

Clin Pharmacol Ther. 1982 Jul;32(1):7-11. doi: 10.1038/clpt.1982.119.

DOI:10.1038/clpt.1982.119

Abstract

Immersion of the hand into ice water (cold-pressor test) in nine hypertensive subjects induced elevation of mean blood pressure, increase of vascular resistance in the extremities, decrease of blood flow in the extremities, and increase in heart rate. The preejection phase of systole was not altered. Indoramin and propranolol, each alone and together, attenuated the pressor and other cardiovascular responses. Submaximal exercise increased heart rate during placebo treatment, a response only partially attenuated by indoramin, propranolol, and their combination, but it did not induce changes in mean blood pressure during any of the treatments.

摘要

将九名高血压患者的手浸入冰水中（冷加压试验）会导致平均血压升高、四肢血管阻力增加、四肢血流量减少以及心率加快。收缩期的射血前期未发生改变。吲哚拉明和普萘洛尔单独使用以及联合使用时，均可减弱升压反应和其他心血管反应。在安慰剂治疗期间，次极量运动可使心率增加，吲哚拉明、普萘洛尔及其联合用药仅能部分减弱这一反应，但在任何一种治疗期间，次极量运动均未引起平均血压变化。