Wambach G, Helber A, Bönner G, Hummerich W, Konrads A, Meurer K A
Dtsch Med Wochenschr. 1982 Jun 18;107(24):923-7. doi: 10.1055/s-2008-1070047.
The regulation of aldosterone secretion by sodium restricted and enriched diet was assessed in 21 patients with primary aldosteronism for differentiation between unilateral aldosterone-producing adenoma and adrenocortical hyperplasia causing autonomous aldosterone hypersecretion. Compared to 10 patients with idiopathic adrenocortical hyperplasia, urinary aldosterone excretion after 4 days of sodium restricted diet was significantly higher in 11 patients with established adenoma (41.3 +/- 16.3 micrograms/24 h vs 19.8 +/- 8.5 micrograms/24 h; P less than 0.005). After six days of sodium loading these differences became even more obvious (35.3 +/- 14.0 micrograms/24 h vs 12.7 +/- 3.7 micrograms/24 h; P less than 0.0005). Sodium excretion did not influence aldosterone secretion in the adenoma group. In patients with hyperplasia both parameters showed a negative correlation (r = -0.522; P less than 0.001). Differentiation without overlap between both patient groups was achieved by comparison of the quotient of aldosterone excretion and serum potassium level during sodium enriched diet.
对21例原发性醛固酮增多症患者进行钠限制和钠丰富饮食对醛固酮分泌的调节评估，以区分单侧醛固酮分泌腺瘤和导致自主性醛固酮分泌过多的肾上腺皮质增生。与10例特发性肾上腺皮质增生患者相比，11例确诊腺瘤患者在钠限制饮食4天后尿醛固酮排泄量显著更高（41.3±16.3微克/24小时对19.8±8.5微克/24小时；P<0.005）。钠负荷6天后，这些差异变得更加明显（35.3±14.0微克/24小时对12.7±3.7微克/24小时；P<0.0005）。腺瘤组中钠排泄不影响醛固酮分泌。增生患者中这两个参数呈负相关（r=-0.522；P<0.001）。通过比较钠丰富饮食期间醛固酮排泄量与血清钾水平的商数，实现了两组患者之间无重叠的区分。
