Oka E, Fujita C, Ohtahara S, Yamatogi Y, Nishimoto A
No To Shinkei. 1978 Aug;30(8):923-8.
A follow-up study was carried out on 12 children with vasopressin sensitive diabetes insipidus. 1) Nine cases (75%) of 12 were finally diagnosed as having brain tumor in later course. There were 3 cases (25%) who could not be decided as having brain tumor during the follow-up period of more than 6 years. 2) There was one case who developed the overt signs of brain tumor 9 years after the onset of diabetes insipidus. Therefore, it seems necessary to follow-up cases with diabetes insipidus for at least 10 years before determining it as idiopathic type. 3) In cases with diabetes insipidus due to brain tumor, associated growth retardation, autonomic symptoms, behavior disorder, endocrine dysfunction and metabolic dysfunction were frequently observed. In the case where these symptoms become aggravated with lapse of time, these findings should be taken seriously as indicating brain tumor. 4) In the case showing either anterior or posterior focal slow waves in the EEG, if such focal slow waves aggravate with age, the findings should be considered as indicative of brain tumor. 5) We would like to emphasize the significance of brain tumor as the underlying pathology of childhood diabetes insipidus.
对12例血管加压素敏感性尿崩症患儿进行了随访研究。1）12例中有9例（75%）最终在病程后期被诊断为患有脑肿瘤。有3例（25%）在超过6年的随访期内无法确定是否患有脑肿瘤。2）有1例在尿崩症发病9年后出现了明显的脑肿瘤体征。因此，在将尿崩症确定为特发性类型之前，对尿崩症病例进行至少10年的随访似乎是必要的。3）在因脑肿瘤导致尿崩症的病例中，经常观察到伴有生长发育迟缓、自主神经症状、行为障碍、内分泌功能障碍和代谢功能障碍。如果这些症状随着时间的推移而加重，应认真对待这些发现，因为它们提示可能存在脑肿瘤。4）在脑电图显示有前部或后部局灶性慢波的病例中，如果这种局灶性慢波随着年龄增长而加重，这些发现应被视为提示脑肿瘤。5）我们想强调脑肿瘤作为儿童尿崩症潜在病理基础的重要性。
