足月儿、早产儿和患病婴儿的血清游离甲状腺素值。

Serum free thyroxine values in term, premature, and sick infants.

作者信息

Wilson D M, Hopper A O, McDougall I R, Bayer M F, Hintz R L, Stevenson D K, Rosenfeld R G

出版信息

J Pediatr. 1982 Jul;101(1):113-7. doi: 10.1016/s0022-3476(82)80198-4.

Abstract

Free thyroxine concentrations were determined by radioimmunoassay in 96 infants within an intensive care nursery and in 32 healthy term infants. Sera for free T4 levels were drawn simultaneously with the filter paper specimens for T4 obtained to screen these infants for congenital hypothyroidism. The mean free T4 level in 20 adults was 1.38 +/- 0.03 ng/dl (mean +/- SEM). The mean in the ICN infants was 3.48 +/- 0.18 ng/dl and in healthy term infants, 4.24 +/- 0.23 ng/dl. Like T4, free T4 correlated positively with increasing gestational age and birth weight, and was lower in infants with RDS. Although 66% of the ICN infants had T4 levels below the statistically selected screening level (fifth percentile), all of these infants had free T4 levels greater than 0.8 ng/dl. Two additional infants with untreated congenital hypothyroidism has free T4 levels of 0.3 and 0.4 ng/dl. The measurement of free T4 appears to be an accurate indicator of thyroid function in these infants.

摘要

采用放射免疫分析法测定了96名重症监护病房婴儿和32名足月健康婴儿的游离甲状腺素浓度。在采集用于筛查这些婴儿先天性甲状腺功能减退症的滤纸标本以检测T4的同时，采集了用于检测游离T4水平的血清。20名成年人的平均游离T4水平为1.38±0.03 ng/dl（平均值±标准误）。重症监护病房婴儿的平均水平为3.48±0.18 ng/dl，足月健康婴儿为4.24±0.23 ng/dl。与T4一样，游离T4与胎龄和出生体重的增加呈正相关，在患有呼吸窘迫综合征的婴儿中较低。尽管66%的重症监护病房婴儿的T4水平低于统计学选定的筛查水平（第五百分位数），但所有这些婴儿的游离T4水平均高于0.8 ng/dl。另外两名未经治疗的先天性甲状腺功能减退症婴儿的游离T4水平分别为0.3和0.4 ng/dl。游离T4的测定似乎是这些婴儿甲状腺功能的准确指标。