在志愿者中，0.8%的氯美噻唑输注产生的溶血作用最小。氯美噻唑输注与溶血。

Minimal haemolytic effects from 0.8% chlormethiazole infusion in volunteer subjects. Chlormethiazole infusion and haemolysis.

作者信息

Seow L T, Ryall R G

出版信息

Anaesthesia. 1982 Jun;37(6):646-50. doi: 10.1111/j.1365-2044.1982.tb01276.x.

DOI:10.1111/j.1365-2044.1982.tb01276.x

Abstract

A solution of 0.8% chlormethiazole ethanedisulphonate was infused into the antecubital vein of 14 healthy volunteers for periods ranging from 60 to 120 minutes to examine any haemolytic effects in vivo. Plasma haptoglobin and haemopexin concentrations were measured before, during and after infusion. No evidence of intravascular haemolysis of any clinical significance was found.

摘要

将0.8%的氯美噻唑乙磺酸盐溶液注入14名健康志愿者的肘前静脉，持续时间为60至120分钟，以检查体内的溶血作用。在输注前、输注期间和输注后测量血浆触珠蛋白和血红素结合蛋白浓度。未发现具有任何临床意义的血管内溶血证据。