小鼠腭裂易感性与主要组织相容性复合体（H-2）

Susceptibility to cleft palate and the major histocompatibility complex (H-2) in the mouse.

作者信息

Vekemans M, Fraser F C

出版信息

Teratology. 1982 Apr;25(2):267-70. doi: 10.1002/tera.1420250216.

DOI:10.1002/tera.1420250216

Abstract

The congenic mouse strains B10 and B10.A differ genetically only at the H-2 locus, B10 having the H-2b and B10.A the H-2a haplotype. The two strains also differ in susceptibility to cortisone-induced cleft palate, B10 being more resistant than B10.A. Since stage of palate closure is also associated with susceptibility to cortisone-induced cleft palate it was postulated that the H-2 haplotype may affect the cortisone-induced cleft palate susceptibility by altering the stage of palate closure. The present study shows that palate closure occurs at the same stage in the two strains, so this hypothesis must be rejected.

摘要

同源近交系小鼠B10和B10.A仅在H-2基因座上存在遗传差异，B10具有H-2b单倍型，而B10.A具有H-2a单倍型。这两个品系对可的松诱导的腭裂的易感性也不同，B10比B10.A更具抗性。由于腭裂闭合阶段也与可的松诱导的腭裂易感性相关，因此推测H-2单倍型可能通过改变腭裂闭合阶段来影响可的松诱导的腭裂易感性。本研究表明，这两个品系的腭裂闭合发生在同一阶段，因此该假设必须被摒弃。

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