双侧精索静脉曲张所致不育症患者的人类睾丸脂质组成。

The lipid composition of human testis in patients with bilateral varicocele as cause of infertility.

作者信息

Sheriff D S

出版信息

Andrologia. 1982 Mar-Apr;14(2):150-3. doi: 10.1111/j.1439-0272.1982.tb03117.x.

DOI:10.1111/j.1439-0272.1982.tb03117.x

Abstract

The lipid composition of human testis in patients with bilateral varicocele as cause of infertility is presented. The total lipids formed 1.90 percent of the total wet weight of the tissue. Testicular cholesterol formed 26.50 percent, glycerides 28.50 percent and phospholipids 45 percent of the total lipids. The increase observed in total cholesterol, glycerides in the testis of patients with bilateral varicocele compared to the control group appears to suggest that non-utilization of cholesterol esters for androgen biosynthesis. Androgen deficiency would result in inhibition of spermatogenesis as shown by the histological examination of the bilateral testicular biopsy specimens. Testicular neutral lipids get altered whenever there is imparied steroidogenesis and spermatogenesis. Thus, testicular lipids may taken as one of the important indices of testicular function.

摘要

本文介绍了因双侧精索静脉曲张导致不育的患者睾丸的脂质组成。总脂质占组织总湿重的1.90%。睾丸胆固醇占总脂质的26.50%，甘油酯占28.50%，磷脂占45%。与对照组相比，双侧精索静脉曲张患者睾丸中的总胆固醇和甘油酯增加，这似乎表明胆固醇酯未用于雄激素生物合成。如双侧睾丸活检标本的组织学检查所示，雄激素缺乏会导致精子发生受到抑制。每当类固醇生成和精子发生受损时，睾丸中性脂质就会发生改变。因此，睾丸脂质可被视为睾丸功能的重要指标之一。