Behavioral and electrophysiological analyses of the effects of 2-o-chlorobenzoyl-4-chloro-n-methyl-n alpha-glycylglycinanilide hydrate (45-0088-S) in the CNS in cats and monkeys.

Behavioral and electrophysiological comparative analyses of the effects of 2-o-chlorobenzoyl-4-chloro-N-methyl-N alpha-glycylglycinanilide hydrate (45-0088-S) and diazepam on the CNS were performed with cats and monkeys. No essential difference between 45-0088-S and diazepam on the effects in the CNS was observed, although the "taming" effect in wild cats and the hypnotic effect in monkeys caused by 45-0088-S were stronger than those of diazepam. The sleep-wakefulness cycles in both cats and monkeys were modified by 45-0088-S. The activity of the reticular formation, hypothalamus and amygdala in cats was inhibited by 45-0088-S and by diazepam.