纳洛酮对自发性高血压大鼠和正常血压大鼠血压、镇痛及利尿作用的影响。

Naloxone effects on blood pressure, analgesia and diuresis in spontaneous hypertensive and normotensive rats.

作者信息

Delbarre B, Casset-Senon D, Delbarre G, Sestillange P, Christin O

出版信息

Neurosci Lett. 1982 May 28;30(2):167-72. doi: 10.1016/0304-3940(82)90291-9.

Abstract

Studies were performed in unanesthetized normotensive and spontaneously hypertensive rats (SHR) to compare the effects of naloxone. In normotensive Wistar rats, naloxone did not change blood pressure (BP) and nociceptive threshold, but it induced a dose-related diuretic response. Whereas in SHR naloxone decreased nociceptive threshold and lowered BP when given intracerebroventricularly, it failed to significantly modify diuresis. These differences between hypertensive and normotensive rats in their responses to naloxone may be explained by the fact that vasopressin (VP) levels and opioid activity are different in SHR.

摘要

在未麻醉的正常血压大鼠和自发性高血压大鼠（SHR）中进行了研究，以比较纳洛酮的作用。在正常血压的Wistar大鼠中，纳洛酮不会改变血压（BP）和痛觉阈值，但会诱导剂量相关的利尿反应。而在SHR中，脑室内注射纳洛酮会降低痛觉阈值并降低血压，但它未能显著改变利尿作用。高血压大鼠和正常血压大鼠对纳洛酮反应的这些差异可能是由于SHR中血管加压素（VP）水平和阿片类活性不同这一事实所解释的。