Olsson S E, Stavenborn M, Hoppe F
Acta Vet Scand. 1982;23(1):65-78. doi: 10.1186/BF03546823.
The authors report the radiographic and pathologic findings in 10 Great Dane dogs with the wobbler syndrome. In all 10 dogs it was possible to demonstrate myelographically that there was cervical spinal cord compression at 1 or 2 sites. The spinal cord compression was mainly dynamic in nature, as degree of compression increased in extension and decreased in flexion of the neck in 8 dogs. In 1 dog with deformed vertebral bodies (G6 and C7), compression increased slightly in flexion of the neck. In another dog, compression was lateral and could only be seen in the ventrodorsal view. The macroscopic findings substantiated the radiologic findings. The cause of the spinal cord compression was in 8 dogs a decrease in the dorsoventral diameter of the orifice of the vertebral canal of 1 or 2 vertebrae in combination with deformation and elongation of 1 or several vertebral arches. In extension of the neck, the cervical spinal cord was squeezed between the anterior tip of the elongated vertebral arch and the caudodorsal rim of the body of the adjacent cranial vertebra. Histologic examination was made of the spinal cord in 5 dogs and the compressive lesions that were found could explain the neurologic signs. In the discussion, the question is raised as to why pain is not a prominent sign in dogs with the wobbler syndrome in contrast to in dogs with cervical disc protrusion. It is believed that the inflammatory foreign body reaction, triggered by the protruded calcified nucleus pulposus is the main cause of pain in the disc protrusion syndrome. In the wobbler syndrome there is no obvious inflammatory reaction in the epidural space. Finally, the possible etiologic factors oC importance for the deformation oC the cervical vertebrae in wobblers are discussed. There are indications that both overnutrition and a genetic trait for rapid growth are of importance.
作者报告了10只患有摇摆综合征的大丹犬的放射学和病理学发现。在所有10只犬中，通过脊髓造影都证实了在1个或2个部位存在颈脊髓受压。脊髓受压主要是动态性的，8只犬在颈部伸展时受压程度增加，屈曲时受压程度减小。1只患有椎体畸形（第6和第7颈椎）的犬，颈部屈曲时受压略有增加。另1只犬的受压是侧向的，仅在腹背位片上可见。大体检查结果证实了放射学检查结果。8只犬脊髓受压的原因是1个或2个椎体椎管孔径的背腹径减小，同时伴有1个或多个椎弓的变形和延长。在颈部伸展时，颈脊髓被拉长的椎弓前端与相邻上位椎体的尾背缘挤压。对5只犬的脊髓进行了组织学检查，发现的压迫性病变可以解释神经症状。在讨论中，提出了一个问题，即为什么与颈椎间盘突出症的犬相比，摇摆综合征的犬疼痛不是一个突出的症状。据信，突出的钙化髓核引发的炎症异物反应是椎间盘突出综合征疼痛的主要原因。在摇摆综合征中，硬膜外间隙没有明显的炎症反应。最后，讨论了对摇摆综合征中颈椎变形可能具有重要意义的病因学因素。有迹象表明，营养过剩和快速生长的遗传特征都很重要。
