Bluet-Pajot M T, Durand D, Mounier F, Schaub C, Kordon C
J Endocrinol. 1982 Sep;94(3):327-31. doi: 10.1677/joe.0.0940327.
The beta-adrenergic agonist, isoprenaline, and antagonist, propranolol, had no effect on the delayed basal secretion of GH consistently observed in rats treated with the narco-analgesic gamma-hydroxybutyrate. Under the same experimental conditions, GH release was distinctly stimulated by infusion of the alpha-adrenergic agonist, clonidine, and by morphine; both responses were dose-dependent. The effects of beta-adrenergic agonists and antagonists on these GH responses were as follows: in rats pretreated with isoprenaline -the GH release induced by clonidine and morphine was abolished whereas it was enhanced in rats pretreated with propranolol. These data confirmed and extended previous reports from this laboratory on the inhibitory role of beta-adrenergic receptors on GH regulation.
β-肾上腺素能激动剂异丙肾上腺素和拮抗剂普萘洛尔，对用麻醉性镇痛药γ-羟基丁酸治疗的大鼠中持续观察到的生长激素延迟基础分泌没有影响。在相同的实验条件下，α-肾上腺素能激动剂可乐定的输注和吗啡可明显刺激生长激素释放；两种反应均呈剂量依赖性。β-肾上腺素能激动剂和拮抗剂对这些生长激素反应的影响如下：在用异丙肾上腺素预处理的大鼠中，可乐定和吗啡诱导的生长激素释放被消除，而在用普萘洛尔预处理的大鼠中则增强。这些数据证实并扩展了本实验室先前关于β-肾上腺素能受体对生长激素调节的抑制作用的报道。
