Kerbs S, Allen A M
J Invest Dermatol. 1978 Nov;71(5):301-4. doi: 10.1111/1523-1747.ep12529256.
The effect of occlusion and griseofulvin on the duration and severity of acute dermatophytosis was assessed in guinea pigs. Sixty guinea pigs given standard Trichophyton mentagrophytes infections were divided into 5 groups: (A) control, (B) intermittent wet occlusion, (C) continuous-wet occlusion, (D) griseofulvin, (E) griseofulvin-continuous-wet occlusion. Lesions were largest in the control group, smallest in the griseofulvin-continuous-occlusion group, and of intermediate area in the other groups. The degree of inflammation and alopecia was not affected by occlusion, but was markedly reduced or eliminated with griseofulvin. Healing of the lesions occurred more rapidly in the griseofulvin-continuous-occlusion group than in any other group. This study suggests that either occlusion of the inoculated site or oral griseofulvin markedly reduces the expected area of the fungal lesion, and occlusion together with griseofulvin shortens the duration of the lesion.
在豚鼠身上评估了封闭和灰黄霉素对急性皮肤癣菌病病程和严重程度的影响。60只感染标准须癣毛癣菌的豚鼠被分为5组：(A)对照组，(B)间歇性湿封包组，(C)持续性湿封包组，(D)灰黄霉素组，(E)灰黄霉素-持续性湿封包组。皮损在对照组中最大，在灰黄霉素-持续性封包组中最小，在其他组中面积居中。炎症和脱发程度不受封包影响，但使用灰黄霉素后明显减轻或消除。皮损愈合在灰黄霉素-持续性封包组比其他任何组都更快。本研究表明，接种部位的封包或口服灰黄霉素均可显著减小预期的真菌皮损面积，封包与灰黄霉素联合使用可缩短皮损病程。
