McCandless D M, Schwartzenburg F C
Neurochem Res. 1982 Jul;7(7):811-9. doi: 10.1007/BF00965674.
Pentylenetetrazole was administered to Swiss-Albino mice, producing clonic-tonic seizures. Other groups were pretreated with one of the three anticonvulsants: phenytoin, clonazepam, or sodium valproate. Mice were sacrificed during the preseizure (1 minute) stage and at the onset of clonic-tonic seizures (2 minutes). Glucose, glycogen, ATP, and phosphocreatine were measured in layers of the parietal cortex and cerebellar vermis. Cortical metabolites were unchanged, or increased slightly, suggesting decreased utilization. In both cerebellar layers, glucose and glycogen were significantly decreased, and phosphocreatine was decreased in the molecular layer. These results indicate a regionally selective effect for pentylenetetrazole on cerebral energy metabolites. Pretreatment with anti-convulsants reduced the severity of the seizure, and eliminated the effect of pentylenetetrazole on glucose and glycogen.
向瑞士白化小鼠注射戊四氮，引发阵挛 - 强直惊厥。其他组用三种抗惊厥药物之一进行预处理：苯妥英、氯硝西泮或丙戊酸钠。在惊厥前（1分钟）阶段和阵挛 - 强直惊厥发作时（2分钟）处死小鼠。测定顶叶皮质和小脑蚓部各层的葡萄糖、糖原、三磷酸腺苷（ATP）和磷酸肌酸。皮质代谢物未发生变化或略有增加，提示利用率降低。在小脑的两层中，葡萄糖和糖原显著减少，分子层中的磷酸肌酸减少。这些结果表明戊四氮对脑能量代谢物具有区域选择性作用。用抗惊厥药物预处理可降低惊厥的严重程度，并消除戊四氮对葡萄糖和糖原的影响。
