Kumar S, Antony M, Mehrotra N K
Toxicology. 1982;23(4):347-52. doi: 10.1016/0300-483x(82)90072-5.
Skin painting with 30 microliter of jute batching oil (JBO) for 8 days resulted in increased gross liver weight, microsomal protein content and benzo[alpha]pyrene hydroxylase activity of liver. Skin benzo[alpha]pyrene hydroxylase activity at the treated site increased by 10-fold. An investigation of cytochrome pigment status in liver and skin of treated animals showed a specific increase in P-448 level in both tissues. Single skin applications of JBO elevated the level of skin and liver benzo[alpha]pyrene hydroxylase activity to its maximum after 1 day and 2 days, respectively, which, in absence of further treatment with mineral oil, declined gradually to normal levels in due course. The results suggest that single or multiple cutaneous exposure(s) with JBO can increase carcinogen metabolising status of skin and liver which may be one of the causative factors for the tumorigenic effects of JBO in skin.
用30微升黄麻籽油（JBO）进行皮肤涂抹，持续8天，导致肝脏总体重量增加、微粒体蛋白含量增加以及肝脏苯并[a]芘羟化酶活性增强。处理部位的皮肤苯并[a]芘羟化酶活性提高了10倍。对经处理动物的肝脏和皮肤中的细胞色素色素状态进行的调查显示，两个组织中的P - 448水平均有特异性升高。单次皮肤涂抹JBO后，皮肤和肝脏的苯并[a]芘羟化酶活性水平分别在1天和2天后升至最高，在不再用矿物油进一步处理的情况下，随着时间推移逐渐降至正常水平。结果表明，单次或多次皮肤接触JBO可提高皮肤和肝脏的致癌物代谢状态，这可能是JBO对皮肤产生致癌作用的致病因素之一。
