双嘧达莫对冠状动脉闭塞后心肌梗死面积的预防作用。

The prophylactic effect of dipyridamole on the size of myocardial infarction following coronary artery occlusion.

作者信息

Adolfsson J, Tornling G, Unge G, Ljungqvist A

出版信息

Acta Pathol Microbiol Immunol Scand A. 1982 Jul;90(4):273-5. doi: 10.1111/j.1699-0463.1982.tb00092_90a.x.

DOI:10.1111/j.1699-0463.1982.tb00092_90a.x

Abstract

Experimental myocardial infarction was induced in adult female Sprague-Dawley rats by ligation of the left coronary artery. During four weeks preceding the operation the animals were given dipyridamole (3 mg/kg initial body weight) i.p. twice a day 5 days per week. Control animals were given saline. Ten days after the operation the rats were killed and the hearts serially sectioned and stained. The volumes of necrotic and non-necrotic myocardial tissue were determined by morphometry on the histological sections. In the dipyridamole-treated animals the volume of non-necrotic myocardium was larger and the necrotic tissue volume smaller than in the control animals.

摘要

通过结扎左冠状动脉，在成年雌性斯普拉格-道利大鼠中诱导实验性心肌梗死。在手术前的四周内，每周5天，每天两次腹腔注射双嘧达莫（初始体重3 mg/kg）。对照动物注射生理盐水。术后10天处死大鼠，将心脏连续切片并染色。通过组织学切片上的形态计量学确定坏死和非坏死心肌组织的体积。与对照动物相比，双嘧达莫治疗的动物中非坏死心肌的体积更大，坏死组织的体积更小。