Lilis R, Valciukas J A, Kon S, Sarkosi L, Campbell C, Selikoff I J
Am J Ind Med. 1982;3(1):33-51. doi: 10.1002/ajim.4700030107.
This study of an occupationally lead-exposed group in the automobile assembly industry (body shop employees) has provided information with regard to current and recent lead-exposure levels characteristic for these operations. Comparison with findings in other, previously studied occupational groups (secondary smelter workers) indicated that current and recent lead exposure was significantly lower in the autobody shop employees. Prevalence of symptoms was found to be higher than in a control, non-lead-exposed group of maintenance workers in the same plant, but the differences reached the level of statistical significance only sporadically. Long-term effects on renal function, as reflected in blood urea nitrogen (BUN) and creatinine levels, were documented to be significant in this group of autobody shop employees. When compared with two secondary lead smelter populations previously studied, correlations between indicators of renal function, BUN and creatinine, and duration of lead exposure were consistently higher in the secondary lead smelter populations than in the group of autobody shop employees, although duration of lead exposure was greater in the latter. These findings are consistent with a dose-response relationship with regard to renal function impairment due to lead absorption. An increased prevalence of hypertension, especially diastolic, was also found, probably the consequence of renal effect.
这项针对汽车装配行业职业性铅暴露人群(车身车间员工)的研究,提供了有关这些作业当前及近期铅暴露水平特征的信息。与其他先前研究过的职业群体(二次冶炼厂工人)的研究结果相比,表明车身车间员工当前及近期的铅暴露水平显著更低。症状的患病率高于同一工厂中未接触铅的维修工人对照组,但差异仅偶尔达到统计学显著水平。在这组车身车间员工中,血尿素氮(BUN)和肌酐水平所反映的对肾功能的长期影响被证明是显著的。与之前研究过的两个二次铅冶炼人群相比,尽管车身车间员工的铅暴露时间更长,但二次铅冶炼人群中肾功能指标BUN和肌酐与铅暴露持续时间之间的相关性始终高于车身车间员工组。这些发现与铅吸收导致肾功能损害的剂量反应关系一致。还发现高血压患病率增加,尤其是舒张压升高,这可能是肾脏影响的结果。