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[氟桂利嗪对脑静脉流出及脑氧消耗的影响]

[Effects of flunarizine on cerebral venous outflow and cerebral oxygen consumption].

作者信息

Kubo K, Jageneau T

出版信息

Nihon Yakurigaku Zasshi. 1982 Jun;79(6):529-41.

PMID:7129242
Abstract
  1. Flunarizine (0.3 and 1 mg/kg, i.v.) and papaverine (1 mg/kg, i.v.) caused significant increases in cerebral blood flow and decreases in cerebral vascular resistance with concomitant increases in cerebrospinal fluid pressure, in spite of decreases in systemic blood pressure. The duration of these effects by flunarizine were longer than those by papaverine. 2) Heart rate increased markedly with papaverine, while it decreased with flunarizine only at a dose of mg/kg, i.v. Central venous pressure increased slightly and temporarily with flunarizine, but it was not changed with papaverine. 3) Cerebral arteriovenous oxygen difference decreased with either of the drugs at a a dose of 1 mg/kg, i.v. Meanwhile, cerebral oxygen consumption was not affected by flunarizine or papaverine. 4) Either of the drugs increased the PO2 of the cerebral venous blood temporarily and slightly, but significantly, as well as the end tidal CO2 concentration. These results suggested that flunarizine has a longer acting cerebral vasodilatating effect that papaverine does without any effect on the cerebral oxygen consumption.
摘要
  1. 氟桂利嗪(静脉注射0.3和1毫克/千克)和罂粟碱(静脉注射1毫克/千克)可使脑血流量显著增加,脑血管阻力降低,同时脑脊液压力升高,尽管全身血压有所下降。氟桂利嗪的这些作用持续时间比罂粟碱长。2) 罂粟碱使心率显著增加,而仅在静脉注射1毫克/千克剂量的氟桂利嗪时心率降低。氟桂利嗪使中心静脉压略有短暂升高,但罂粟碱对其无影响。3) 静脉注射1毫克/千克剂量的任何一种药物均可使脑动静脉氧差降低。同时,氟桂利嗪或罂粟碱均不影响脑氧耗量。4) 两种药物均可使脑静脉血PO2暂时轻微但显著升高,以及使呼气末CO2浓度升高。这些结果表明,氟桂利嗪具有比罂粟碱更长时间的脑血管舒张作用,且对脑氧耗量无影响。

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