补体C4的遗传学。一个家族中的两种纯合重复单倍型C4S C4S和C4F C4F。
Genetics of complement C4. Two homoduplication haplotypes C4S C4S and C4F C4F in a family.
作者信息
Bruun-Petersen G, Lamm L U, Jacobsen B K, Kristensen T
出版信息
Hum Genet. 1982;61(1):36-8. doi: 10.1007/BF00291328.
A family in which two homoduplicated C4 haplotypes (or supergenes) segregate is described. One haplotype C4F3 C4F2.2 is composed of two C4F alleles and the other C4S5.1 C4S1 of two C4S alleles. The C4F duplication haplotype is a partial inhibitor of the Rodgers antigen, and judged from our family and population material, it seems to be rather frequent and associated with HLAB35, BfF, and HLAD/DR*1. The C4S duplication haplotype is Rg(a-) and is not identified in individuals without another S, Ch(A+) variant.
描述了一个家系，其中两种纯合重复的C4单倍型（或超级基因）发生分离。一种单倍型C4F3 C4F2.2由两个C4F等位基因组成，另一种C4S5.1 C4S1由两个C4S等位基因组成。C4F重复单倍型是Rodgers抗原的部分抑制剂，从我们的家系和群体资料判断，它似乎相当常见，并与HLA - B35、BfF和HLA - D/DR*1相关。C4S重复单倍型是Rg(a -)，在没有其他S、Ch(A +)变体的个体中未被鉴定出来。
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