Alper J C, Bogaars H, Sober A J, Schoenfeld E
J Dermatol Surg Oncol. 1982 Sep;8(9):771-3. doi: 10.1111/j.1524-4725.1982.tb02680.x.
The concept of melanoma "in situ" is discussed pointing out that these lesions have the potential to become invasive tumors if not adequately treated. If such a pathologic diagnosis is made, each margin of the specimen should be carefully checked for the presence of atypical melanocytes. In our experience, with excision margins of 0.5-1 cm, local recurrence has not been a problem.
讨论了黑色素瘤“原位”的概念，指出如果治疗不充分，这些病变有可能发展为浸润性肿瘤。如果做出这样的病理诊断，应仔细检查标本的每个切缘是否存在非典型黑素细胞。根据我们的经验，切除切缘为0.5 - 1厘米时，局部复发不是问题。
J Dermatol Surg Oncol. 1982-9
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