Handler C E, Besse C P, Wilson A O
Postgrad Med J. 1982 Aug;58(682):527-8. doi: 10.1136/pgmj.58.682.527.
A possible case of cimetidine induced extrapyramidal and cerebellar features is reported. Although confusion is a well recognized toxic effect of cimetidine, other neurotoxic features are less common, especially in patients without evidence of renal or hepatic disease. Cimetidine should be used with great care and possibly in a reduced dose in the elderly as neuropsychiatric side effects may occur.
报告了一例可能由西咪替丁引起的锥体外系和小脑症状的病例。虽然意识模糊是西咪替丁一种广为人知的毒性作用,但其他神经毒性症状较少见,尤其是在没有肾脏或肝脏疾病证据的患者中。西咪替丁在老年人中应谨慎使用,可能需减少剂量,因为可能会出现神经精神方面的副作用。