免疫原性葡萄膜炎中的水性免疫复合物。

Aqueous immune complexes in immunogenic uveitis.

作者信息

Howes E L, Char D H, Christensen M

出版信息

Invest Ophthalmol Vis Sci. 1982 Dec;23(6):715-8.

Abstract

A primary immunogenic uveitis was produced in rabbits by the intravitreal injection of bovine plasma albumin or ovalbumin. A secondary or recurrent uveitis was induced by intravenous injection of the specific soluble antigen several months after the cessation of primary inflammation. Aqueous antigen-antibody complexes were studied at times of maximal clinical response in both primary and recurrent forms during resolution of primary immunogenic uveitis, and in a nonspecific protein extravasation induced by aqueous paracentesis. Immune complexes could be demonstrated only during times of clinically evident inflammation in immunogenic uveitis. The results indicate the importance of antigen-antibody complex formation in the pathogenesis of this form of experimental ocular inflammatory disease.

摘要

通过玻璃体内注射牛血清白蛋白或卵清蛋白在兔体内诱发原发性免疫性葡萄膜炎。在原发性炎症消退数月后，通过静脉注射特异性可溶性抗原来诱发继发性或复发性葡萄膜炎。在原发性免疫性葡萄膜炎消退过程中，对原发性和复发性形式在最大临床反应时的房水抗原 - 抗体复合物进行了研究，同时也研究了房水穿刺引起的非特异性蛋白质外渗中的复合物。仅在免疫性葡萄膜炎临床明显炎症期间可检测到免疫复合物。结果表明抗原 - 抗体复合物形成在这种实验性眼部炎症性疾病发病机制中的重要性。