Haile R, Smith P, Read D, Nassim D, Warlow C, Russell W C
J Neurol Sci. 1982 Oct;56(1):1-10. doi: 10.1016/0022-510x(82)90055-7.
We investigated the levels of neutralizing antibodies to measles virus and canine distemper virus (CDV) in 72 multiple sclerosis patients (MS) and matched controls and also examined the frequency and age of onset of a number of childhood illnesses, including measles. The frequency of each childhood illness was not significantly different between cases and controls, but cases did report a later age at measles infection. Our data suggest that the risk of MS is increased by a factor of 1.9 if measles infection occurs between 5 and 9 years of age. A validity survey, based on a questionnaire to general practitioners, suggested substantial inaccuracy in the patients' reports of when they had measles, but the direction and degree of inaccuracy did not appear to be different between cases and controls. We also found higher titres of neutralizing antibodies in cases than controls to both measles virus and CDV, although the CDV difference was not statistically significant. In the light of a significant correlation between measles and CDV titres in both cases and controls, we used paired logistic regression to determine if the case-control difference in titres for each virus could be explained by a confounding effect on one by the other. The numbers were too small, however, to enable us to separate out any independent association of either virus with MS.
我们调查了72例多发性硬化症患者（MS）及其匹配对照中针对麻疹病毒和犬瘟热病毒（CDV）的中和抗体水平，还检查了包括麻疹在内的多种儿童疾病的发病频率和发病年龄。病例组和对照组中每种儿童疾病的发病频率没有显著差异，但病例组报告的麻疹感染年龄较晚。我们的数据表明，如果在5至9岁之间感染麻疹，患MS的风险会增加1.9倍。一项基于向全科医生发放问卷的有效性调查表明，患者报告的麻疹发病时间存在相当大的不准确，但病例组和对照组在不准确的方向和程度上似乎没有差异。我们还发现，病例组针对麻疹病毒和CDV的中和抗体滴度均高于对照组，尽管CDV的差异没有统计学意义。鉴于病例组和对照组中麻疹和CDV滴度之间存在显著相关性，我们使用配对逻辑回归来确定每种病毒的病例对照滴度差异是否可以用一种病毒对另一种病毒的混杂效应来解释。然而，样本数量太少，无法让我们区分任何一种病毒与MS的独立关联。
