食管癌：病因模型

Cancer of the esophagus: a model of causation.

作者信息

Neuberger J S

出版信息

Med Hypotheses. 1982 Sep;9(3):337-42. doi: 10.1016/0306-9877(82)90164-5.

Abstract

Cancer of the esophagus has shown peculiar worldwide geographic clustering; it has also occurred in excess among individuals in lower socioeconomic census tracts of certain cities. These facts have prompted inquiry into its etiology. Emphasis has been given to environmental effects, particularly mechanical and/or irritating processes, dietary deficiency, and a variety of carcinogens. Immunological susceptibility has been considered, although only infrequently. Overall, primary genetic factors have received short shrift in epidemiological investigations of this disease. An hypothesis of stress related cancer in concert with genotypic susceptibility is presented.

摘要

食管癌在全球呈现出独特的地理聚集性；在某些城市社会经济普查地段较低的人群中也有高发情况。这些事实促使人们对其病因进行探究。研究重点一直放在环境影响上，特别是机械性和/或刺激性过程、饮食缺乏以及多种致癌物。免疫易感性也被考虑在内，不过频率不高。总体而言，在这种疾病的流行病学调查中，原发性遗传因素未得到足够重视。本文提出了一个与基因型易感性相关的应激性癌症假说。