系统性红斑狼疮患者血清中的抗体在体外介导的抗体依赖性细胞毒性导致淋巴细胞破坏。
Lymphocyte destruction by antibody-dependent cellular cytotoxicity mediated in vitro by antibodies in serum from patients with systemic lupus erythematosus.
作者信息
Mahowald M L, Dalmasso A P
出版信息
Ann Rheum Dis. 1982 Dec;41(6):593-8. doi: 10.1136/ard.41.6.593.
Abstract
Sera from patients with systemic lupus erythematosus (SLE) were tested for the presence of IgG antilymphocyte antibodies that are capable of mediating antibody-dependent cellular cytotoxicity (ADCC) of peripheral blood lymphocytes (PBL) from normal donors. The effector cells employed were PBL autologous with the target PBL. Positive ADCC responses were obtained with serum from 5 SLE patients with severe active diseases. It is possible that ADCC is a mechanism by which IgG antilymphocyte antibodies in patients with SLE may mediate in-vivo lymphocytolysis.
摘要
对系统性红斑狼疮（SLE）患者的血清进行检测，以确定是否存在能够介导来自正常供体的外周血淋巴细胞（PBL）的抗体依赖性细胞毒性（ADCC）的IgG抗淋巴细胞抗体。所采用的效应细胞与靶PBL是自体的外周血淋巴细胞。5例患有严重活动性疾病的SLE患者的血清获得了阳性ADCC反应。ADCC有可能是SLE患者体内IgG抗淋巴细胞抗体介导体内淋巴细胞溶解的一种机制。
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本文引用的文献
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Antibodies to T cells in patients with systemic lupus erythematosus can induce antibody-dependent cell-mediated cytotoxicity against human T cells.系统性红斑狼疮患者体内针对T细胞的抗体可诱导对人T细胞的抗体依赖性细胞介导的细胞毒性。
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