Klug H
Arch Geschwulstforsch. 1982;52(5):379-84.
The most important pigment of the human organism is the melanin. After a short representation of the most essential reactions of the biosynthesis of eu- and pheomelanins there are discussed some aspects of the formation of melanosomes as well as exhibited the structure of eumelanosomes and pheomelanosomes. In the tumour cells of the most melanotic malignant melanomas there can be observed clearly either eumelanosomes or pheomelanosomes. Therefore, two types (Type A and Type B) have been distinguished. One typical tumour cell of both types has been characterized ultrastructurally. A retrospective analysis of electron microscopically investigated melanomas which have been ascertained histologically shows that tumours containing eumelanosomes are more frequent than those with pheomelanosomes.
人体最重要的色素是黑色素。在简要介绍了真黑素和褐黑素生物合成的最基本反应后，讨论了黑素小体形成的一些方面，并展示了真黑素小体和褐黑素小体的结构。在大多数黑素沉着性恶性黑色素瘤的肿瘤细胞中，可以清楚地观察到真黑素小体或褐黑素小体。因此，区分了两种类型（A型和B型）。对两种类型的一个典型肿瘤细胞进行了超微结构特征描述。对经组织学确诊的黑色素瘤进行电子显微镜研究的回顾性分析表明，含有真黑素小体的肿瘤比含有褐黑素小体的肿瘤更常见。
